A character struck by certain monsters such as Devils will become Diseased. The status can also be gained by messing around in Trash Heaps and Sewer Grates. The face of a diseased character is exactly the same as the poisoned face, but it is a little more yellow in color. It is similar to the Poison status, it also decreases all stats, and only 20% of the HP will be present after resting. Ways of curing it includes the Body Magic spell Cure Disease and visiting a Temple.

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